Alcoholic Hepatitis: Steroids vs. Pentoxifylline
نویسندگان
چکیده
منابع مشابه
Pentoxifylline and prednisolone in severe alcoholic hepatitis.
published under the permission of the editor ofWorld J Gastroenterol All authors disclosed that there is no conflict of interest with authors or institutions referred in the manuscript.
متن کاملPrednisolone or pentoxifylline for alcoholic hepatitis.
BACKGROUND Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver impairment that occurs in patients with a history of heavy and prolonged alcohol use. The short-term mortality among patients with severe disease exceeds 30%. Prednisolone and pentoxifylline are both recommended for the treatment of severe alcoholic hepatitis, but uncertainty about their benefit persists. ...
متن کاملSteroids or pentoxifylline for alcoholic hepatitis (STOPAH): study protocol for a randomised controlled trial
BACKGROUND Alcoholic hepatitis is the most florid presentation of alcohol-related liver disease. In its severe form, defined by a Maddrey's discriminant function (DF) ≥32, the 28-day mortality rate is approximately 35%. A number of potential treatments have been subjected to clinical trials, of which two, corticosteroids and pentoxifylline, may have therapeutic benefit. The role of corticostero...
متن کاملPentoxifylline in severe alcoholic hepatitis: a prospective, randomised trial.
BACKGROUND Role of corticosteroids in treatment of severe alcoholic hepatitis (SAH) is controversial. Pentoxifylline (PTX), an inhibitor of TNF, has also been shown to decrease short term mortality in SAH. Aim of this study was to evaluate the effect of PTX on short term mortality, renal and hepatic functions in patients with SAH. METHODS Fifty patients with SAH {Maddrey's Discriminant Functi...
متن کاملTreatment of severe alcoholic hepatitis with corticosteroids and pentoxifylline.
Despite being themost frequently abused drug for centuries, alcohol was not recognized as a direct hepatotoxin until the 1960s.1 Alcohol abuse accounts for the third leading preventable causeofdeath and the secondmost commoncauseof cirrhosis after hepatitis C virus infection in the United States.2,3 Alcoholichepatitis is a commoncomplicationofalcohol abuse; its severity can range frommild to se...
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ژورنال
عنوان ژورنال: Current Hepatitis Reports
سال: 2013
ISSN: 1540-3416,2195-9595
DOI: 10.1007/s11901-012-0158-y